Abstract

Lately, there has been a significant amount of research focus on circadian clock and its impact on human health. It has been shown that disruption of circadian rhythm could lead to cancer and metabolic syndrome. Researchers have identified in a number of murine studies the benefits of time-restricted feeding that can reset the disrupted clock rhythm, which can subsequently optimize the functioning of critical regulatory proteins of metabolism in mice. This has prompted a huge research interest in studying time-restricted feeding in humans for protective actions against cancer and metabolic syndrome and many other complex medical conditions. To this end, a hypothesis based on intermittent fasting for several consecutive days without calorie restriction in humans has been recently clinically tested that has shown an induced anticarcinogenic proteome and the key regulatory proteins of glucose and lipid metabolism for a number of significant health benefits. Here, we present a brief overview on circadian rhythm and its disruption and also the effects of time-restricted feeding to reset the detrimental disruption. We describe recent clinical studies showing potential benefits of intermittent fasting as an adjunct therapy in a number complex medical conditions such as cancer, metabolic syndrome,
and several cognitive and neuropsychiatric diseases.

*Email: megha@biotechkiosk.com
To cite this article: Agrawal M; Can Intermittent Fasting Protect against Cancer, Metabolic Syndrome, Cognitive
and Neuropsychiatric Disease, Biotechnology Kiosk, Vol 2, Issue 5, PP: 5-10 (2020); DOI: https://doi.org/10.37756/bk.20.2.5.1